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The incidence of particular person adverse reactions were not significantly different amongst The 2 regimens. Until percentages are otherwise stipulated, the incidence of unique adverse reactions detailed underneath was lower than one%:
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The looks of irregular neurologic indications requires the prompt discontinuation of metronidazole vaginal gel therapy. Metronidazole vaginal gel should be administered with caution to patients with central nervous technique disorders.
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This probable drug interaction needs to be regarded as when metronidazole vaginal gel is prescribed for sufferers on such a anticoagulant therapy.
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Metronidazole has demonstrated evidence of mutagenic action in several in vitro bacterial assay devices. Furthermore, a dose-reaction boost in the frequency of micronuclei was observed in mice just after intraperitoneal injections and an increase in chromosome aberrations happen to be claimed in clients with Crohn's disease who were treated with 200-1200 mg/working day of metronidazole for 1 to 24 months.
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